Attack of the Mutant Guppies is an episode from the second season of Garfield and Friends.
Garfield's story of giant radioactive mutant guppies turns out to be real after Nermal gets him to investigate.
In the middle of the night, Nermal is sneaking into the kitchen to grab something from the fridge. However unknown to him, Garfield has set a surveillance camera on the top of the fridge to check for snackers. Just as Nermal is about to grab something, Garfield stops him and threatens to send him to Abu Dhabi if he touches any of the food.
Nermal asserts that he's grabbing food for his pet guppy which he was holding during his secret raid. Garfield then tells Nermal that Guppies can be dangerous to which Nermal doesn't believe. He then tells a story about Giant Radioactive Mutant Guppies living in the sewers. According to him they were originally pet guppies that kids didn't want as birthday presents. They would eventually drain them to the sewers where they would mutate from all the chemical that humans would dump there as well. Nermal then says that the story's not true and that they don't exist. Garfield then goes to bed thinking the story will get Nermal out of his food for a while.
Later that night while looking at his guppy Nermal starts to get frightened that Garfield's story may be true and because of that he can't get any sleep. He then wakes Garfield and asks him to take him to the sewer to see if there really are guppies there. Despite admitting that his story was made up and trying to get some sleep, Nermal still tries to get Garfield to check the sewer. Eventually he cracks when Nermal tries to play "Binky's Greatest Hits" and the two cats enter the sewer.
For a while they find nothing in the sewer until they hear roars in the water and soon mutant guppies emerge from the sewers. Realizing that his tall tale was real, Garfield and Nermal try to escape the sewer and evade them but they quickly swarm the two. Nermal asked if this is a dream to which Garfield checks his bed and unfortunately finds it empty implying that it's not a dream.
By now the guppies have cornered the two and Garfield decides to take drastic measures. Running into the garage, he comes out with a barrel full of white stuff which Nermal thinks it's a substance to reverse the radiation. Garfield meanwhile says it's tarter sauce meaning he's planning to eat the guppies for a midnight snack. Realizing what he's going to do, the guppies race back to the sewers with Garfield hot on their tail. Eventually they see the guppies racing down the sewers with Nermal wondering where they're heading. Garfield says that by morning they'll be miles away and they'll never been seen again. He later says it's better that way since he can't find enough French fries to go with them.
A U.S Acres quickie after the episode reveals the Guppies had made their way to Orson's farm through a water well. After scaring Orson and Wade away, the guppies decide to get a guest shot on the "Muppet Babies."
- Giant Radioactive Mutant Guppies
- Girl (voiced by Desirée Goyette)
- Nermal's Guppy
- The guppies show up in the following U.S. Acres Quickie.
- Odie appears in the title card.
- Nermal prepares to play Binky's Greatest Hits to get Garfield out of bed.