George Lowe (born November 10, 1958) is an American voice actor and comedian.

Lowe may be best known as the voice of Space Ghost in Space Ghost Coast to Coast and the original incarnation of Cartoon Planet, both produced by Ghost Planet Industries (now Williams Street Productions). He has also been heard in other shows produced by Williams Street- sometimes reprising his role as Space Ghost- including Aqua Teen Hunger Force, The Brak Show, Perfect Hair Forever, Robot Chicken, and Squidbillies. He was the announcer for the video game Cartoon Network: Punch Time Explosion.

Lowe has been heard on radio stations such as WZXL, WNCX, and WWJB. Among the shows he performs on are Fox Monday and Lowe on the Bone.